The Molecular and Behavioral Neuroscience Research Group focuses on understanding molecular and circuit-level alterations in rodent models of psychiatric conditions including schizophrenia, fear and anxiety disorders. Our research employs a variety of techniques, including behavior test batteries, immunofluorescence, optogenetics, and chemogenetics (DREADDs) Currently, our investigations aim to identify physiological and pathological alterations in hippocampal activity patterns mediated by neuropeptides and their correlation with behavior. We utilize transgenic rodents to pinpoint specific cell populations and their roles in dysregulated defensive reactions. In addition, another major focus of the project is to investigate how early-life adversity influences stress responses in adulthood. Using rodent models, the project examines whether lifestyle-based interventions can modify these effects through changes in the amygdala and hippocampus.

 

In addition to animal models, our research extends to translational studies on fear and cognitive processes involving human participants. To address this, we employ neuroimaging methods such as functional near-infrared spectroscopy (fNIRS), electroencephalography (EEG), eye tracking, and a comprehensive neuropsychological test battery. Our ongoing research examines the neural basis of moral decision-making by comparing traditional and realistic moral dilemmas using fNIRS. We are also investigating cognitive markers of healthy aging and age-related cognitive decline, with a particular focus on neurodegenerative disorders, through the application of fNIRS methodologies.

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